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Controlled Substances Act (CSA)

The main federal law that regulates drugs, placing them into different 'schedules' based on their medical use, potential for abuse, and safety.

Schedule I Controlled Substances

The most restrictive category of drugs under the CSA, designated for substances with a high potential for abuse, no currently accepted medical use, and a lack of accepted safety for use under medical supervision (e.g., heroin, LSD). Being listed here invokes existing federal penalties for drug offenses.

Nitazenes (2-benzylbenzimidazole opioids)

A class of synthetic opioids that are extremely potent and have been linked to a rise in overdose deaths.

Interim Final Rule

A type of regulation issued by a government agency that takes effect immediately, often to address an urgent issue, but also allows for public comment and potential revisions before becoming a permanent, final rule.

Mu-Opioid Receptor Agonist

A substance that activates specific receptors in the brain, producing effects like pain relief, euphoria, and respiratory depression, typical of opioid drugs.

Isomers

Molecules that have the same chemical formula but a different arrangement of atoms, which can sometimes result in different properties.